Research Studies

Clinical Randomisation of an Antifibrinolytic in Significant Head Injury: CRASH 3

Start Date
June 2013
End Date
January 2019
Co-ordinated by
London School of Health and Tropical Medicine
Local PI
Dr Frank Coffey
Lead Research Practitioner
Lucy Ryan

This was a large international trial  run in the Emergency Department. It was looking at the use of Tranexamic acid for the treatment of significant traumatic brain injury. Tranexamic acid has been used to stop bleeding in elective surgery for many years, and the CRASH 2 Trial highlighted the benefit of this drug in patients who had suffered a trauma and were having a catastrophic bleed. This study wanted to know if giving Tranexamic acid in traumatic brain injuries improves mortality rate.